The Catabolic State

We’ve all been there. It’s when your body hits the wall. It’s when the tiredness really kicks in and you know you’re starting to fall in a hole. That’s when things snowball; your work or training suffers, your immune system drops, and your general quality of life starts to suffer as you become tired and irritable. You know you can perform better but just can’t seem to pick things up.

So what is the catabolic state, exactly?

The chronic catabolic state – as seen in cachexia, hypercatabolism, over-exercise and chronic infection – is an ongoing extension of the catabolic state and results in loss of mean muscle mass and amino acid deficiency that cannot be replaced by amino acids derived from proteins in the diet as the chronic catabolic state inhibits the normal digestive processes.

The catabolic state is a normal function of the body metabolism where the hormonal triggers – such as IL-1, Il-2, Il-6, TNF-alpha, catecholamines and cortisone – released by stress, infection, trauma or exercise turn off the anabolic pathways and food digestion processes and turn on muscle protein digestive processes and energy metabolic processes related to oxidation of amino acids.

A Question of Science – How scientific research led to the creation of Fatigue Reviva

Based on 15 years of research, FATIGUE reviva has been the subject of numerous ground-breaking studies conducted by a dedicated research team at one of Australia’s leading universities.

TOP Nutrition is very excited by the possibilities of FATIGUE reviva in numerous applications to a diverse cross-section of the community. The company is pursuing further university based research into the role of the chronic catabolic state in conditions of chronic fatigue as well as in exercise recovery by sports people.

This product offers a unique metabolic delivery system, and as such has brought interest on a worldwide scale.

This product also has huge export potential because of the wide range of customers it will attract. It is not just sports people who will benefit from this unique product, but also the broader community. People with exceptionally high physical and mental workplace demands may consider trying this product.

Furthermore, people with chronic ill health can often suffer reduced digestive capacity, food intolerances and allergies. This amino acid supplement can provide them with easily absorbed nutrients for facilitating the demands of recovery.

And with a growing media focus on infectious disease and the immune system, TOP Nutrition believes the product will come under great demand.


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2. R. Hugh Dunstan, Diane L- Sparkes, Timothy K. Roberts, Benjamin J. Dascombe: Preliminary Evaluations of a Complex Amino Acid Supplement, Fatigue RevivaTM, to Reduce Fatigue in a Group of Professional Male Athletes and a Group of Males Recruited from the General Public. Food and Nutrition Sciences, 2014, 5, 231-235.

3. T. Roberts, “Sub-Health: The Chronic Catabolic State and the Possible Role of Chronic Infection (abstract).” Singapore: Australian Universities International Alumni Convention, 2007.

4. Bralley JA, Lord RS: Treatment of chronic fatigue syndrome with specific amino acid supplementation. J App Nutr 1994, 46:74-78

5. Aquilani R, Zuccarelli GC, Dioguardi FS, Baiardi P, Frustaglia A, Rutili C, Comi E, Catani M, Iadarola P, Viglio S, et al: Effects of oral amino acid supplementation on long term care acquired infections in elderly patients. Arch Gerontol Geriatr 2011, 52(3):e123

6. Bassit RA, Sawada LA, Bacurau RFP, Navarro F, Cosat Rosa LFBP: The effect of BCAA supplementation upon immune response of triathletes. Med Sc Sports Exerc 2000, 32(7): 1214-1219

7. Blomstrand E, Hassmen P, Ekblom B, Newsholme EA: Administration of branched-chain amino acids during sustained exercise – effects on performance and on plasma concentration of some amino acids. Eur J Appl Physiol 1991, 63:83-88

8. R. H. Dunstan, N. R. McGregor, H. L. Butt, T. K. Roberts, I. J. Klineberg, S. H. Niblett, T. Rothkirch and I. Buttfield, “Characterization of Differential Amino Acid Homeostasis amongst Population Subgroups: A Basis for Determining Specific Amino Acid Requirements,” Journal of Nutritional and Environmental Medicine, Vol. 10, No. 3, 2000, pp. 211-223.

9. Australian Government, “Australia New Zealand Food Standards Codes,” 2016.

10. K. D. Tipton, A. A. Ferrando, S. M. Phillips, D. Doyle Jr, and R. R. Wolfe, “Post exercise Net Protein Synthesis in Human Muscle from Orally Administered Amino Acids, American Journal of Physiology- Endocrinology and Metabolism, Vol. 276, 1999, 99. E628-E634.

11. J.L. Bowtell, “Protein and Amino Acid Requirements for Athletes,  American Journal of Physiology-Endocrinology and Metabolism, Vol. 276, 1999, pp. E628-E634.